Acquisition of Ophthalmic Bispecific Antibody Product Assets

Company News

The board (the “Board”) of directors (the “Directors”) of China Medical System Holdings Limited (the “Company”, together with its subsidiaries, the “Group”) is pleased to announce that on 26 July 2022, the Group through a wholly-owned subsidiary of the Company – an ophthalmology business company (“CMS Ophthalmology”) entered into an Asset Transfer Agreement (the “Agreement”) with Wuhan YZY Biopharma Co., Ltd (“YZY Biopharma”), a biopharmaceutical company, to acquire all the assets related to VEGF/ANG2 tetravalent bispecific antibody for intravitreal injection (the “Bispecific Antibody Product”) in the world (the “Territory”) from YZY Biopharma (the “Acquisition”).

In accordance with the Agreement, the assets related to the Bispecific Antibody Product in the Territory (the “Bispecific Antibody Product Assets”) include but are not limited to (i) all necessary rights and assets to use, develop, register, manufacture, commissioned manufacture, sell, distribute, promote and commercialize the Bispecific Antibody Product in the Territory and (ii) all intellectual property and intellectual property rights relevant to the Bispecific Antibody Product owned or controlled by YZY Biopharma or its affiliates.


The Bispecific Antibody Product is a Class 1 Innovative Biological Product with a unique nanobody design for treatment of ocular fundus neovascular diseases, targeting VEGF (vascular endothelial growth factor) and ANG2 (angiopoietin 2), which effectively inhibits abnormal neovascularization through two different pathways. The Bispecific Antibody Product enjoys the advantages of high affinity, strong inhibitory activity, high preparation concentration, good stability and low dosing frequency. It can reduce the potential risks caused by frequent intravitreal injections that occur to the patients and improve medication compliance of patients, possessing important clinical implications. The Bispecific Antibody Product is currently in the preclinical stage.

Ocular fundus neovascular disease, such as neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), etc., is one of the main causes of blindness in the elderly. It is estimated that there are approximately 4 million nAMD patients and 5 million DME patients in Mainland China. Intravitreal injection of anti-VEGF drugs is the standard treatment for ocular fundus neovascularization. According to IQVIA, the market size of mainstream anti-VEGF drugs in Mainland China exceeded RMB3.1 billion in the year of 2021. The Bispecific Antibody Product enjoys differentiation advantages of inhibition through two pathways, high preparation concentration and low dosing frequency, thus is expected to have a broader market in China, and will provide a safer and more effective treatment option for patients with ocular fundus neovascularization.


YZY Biopharma is a biopharmaceutical company specializing in tumor immunotherapy, focusing on the research, development and industrialization of bispecific antibody drugs. YZY Biopharma currently has more than ten products under research and development, covering tumor, infection, neurodegeneration and other fields, and has established a complete antibody drug development industry chain. For additional information about YZY Biopharma and its products, please visit its official website:


The Group has been deeply engaged in the ophthalmology business for years, and has promoted the independent operation of ophthalmology business to improve the operation efficiency and achieve specialized and large-scale development in the ophthalmology field, building China’s leading ophthalmic pharmaceutical and device company covering treatment of all ophthalmic diseases.

CMS Ophthalmology actively identifies, develops and commercializes urgently needed ophthalmological diagnosis and treatment solutions and leading innovative products. The Bispecific Antibody Product will enrich the Group’s innovative product pipeline in the ocular fundus diseases treatment field. The Group made further deployment in the ocular fundus diseases treatment channel through the Acquisition, enhancing the competitiveness in and promoting the rapid development of its ophthalmology business.